Varicella Zoster Virus (VZV) is the causative agent of chicken pox. The virus belongs to the herpes virus family. The person infected develops itchy blisters all over the body.Inmost of the cases it occurs in children younger than 10 years this being the primary encounter with the virus. In some cases, Varicella reactivates in later stage and causes shingles. Shingles are rare in children. But in few cases demonstrating failure in secondary response against chicken pox have been encountered in the age group of 18-24 years. Our survey is mainly directed at understanding the proportions of different factors (like nutrition, stress, BMI, etc.) contributing to the failure of this secondary response. The results interestingly suggest that chickenpox may be acquired twice in a lifetime, depending on multiple factors. © RJPT All right reserved.