To evaluate antidiabetic activity of Chloroxylon swietenia in STZ induced diabetes in albino rats. Forty two albino rats were randomly divided into seven groups (n=6). Diabetes was induced by intraperitoneal injection of streptozotocin (60mg/Kg). Distilled water, Tween 80, glibenclamide, Chloroxylon swietenia aqueous extract (CSAE), ethanolic extracts (CSEE) of 200 and 400mg/kg were given orally for 14 days to the normal control, diabetic control, standard group and test groups respectively. Glucose, TC (total cholesterol), TG (triglyceride), HDL (High density lipoprotein), AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), creatinine, direct bilirubin and indirect bilirubin levels were estimated. ANOVA followed by Student-Newman-Keuls test was used to analyze the data. CSAE of 200mg/kg showed a significant reduction in glucose, ALT, TB and ALP levels in diabetic rats. CSAE of 400mg/kg showed a significant decrease in glucose, AST, ALT, TB, DB and ALP levels in diabetic rats. CSEE of 200mg/kg showed a significant decrease in glucose, ALT, TB, ALP and creatinine levels in diabetic rats. CSEE of 400mg/kg showed a significant decrease in glucose, AST, ALT, TB, DB and ALP levels in diabetic rats. Both extracts show antidiabetic activity in STZ induced diabetes. © 2017 Oriental Scientific Publishing Company. All Rights Reserved.