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Evaluation of DNA Binding with Some Selected Hydrazide and Semicarbazide Derivatives
Janardan S, Suman P, Swapna G, Amrita A, Priya R, , Vijayakrishna K,
Published in Springer Science and Business Media LLC
PMID: 24723202
Volume: 173
Issue: 2
Pages: 596 - 608
A group of hydrazide and semicarbazide derivatives containing isopropylidene, benzylidene, cyclohexylidene, and phospholidene groups was synthesized and characterized by spectroscopic techniques. These compounds were tested for DNA interaction studies monitored by UV-Vis and IR data as well as molecular docking. Investigations on interactions of these compounds with DNA revealed an intercalative mode of binding between them. It is interesting to note that semicarbazide derivatives with aliphatic substituents showed better DNA binding than the aromatic substituents. © 2014 Springer Science+Business Media.
About the journal
JournalData powered by TypesetApplied Biochemistry and Biotechnology
PublisherData powered by TypesetSpringer Science and Business Media LLC
Open Access0