A series of six different ionic liquids (ILs) tailored with different N-alkyl side chains (ethyl, butyl, octyl) were synthesized and evaluated for their vermicidal activity against the Indian earthworm, Pheretima posthuma.

Akella Sivaramakrishna

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Charan K.T.P

Ranjan P

Manojkumar K

Pothanagandhi N

Jha P.C

Khedkar V.M

Vijayakrishna K.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

RSC Advances

Journal of Molecular Liquids

Deciphering the anthelmintic activity of benzimidazolium salts by experimental and in-silico studies

Molecular Diversity

Probing the opportunities for designing anthelmintic leads by sub-structural topology-based QSAR modelling

ChemistrySelect

Appraisal of 1‐Butylimidazole‐Derived Ionic Liquids as Anthelmintic Agents: An Experimental and In Silico Approach

Rational design of imidazolium based salts as anthelmintic agents

Computational Biology and Chemistry

Exploration of interaction zones of β-tubulin colchicine binding domain of helminths and binding mechanism of anthelmintics

Nonviral gene delivery vectors are acquiring greater attention in the field of gene therapy by replacing the biological viral vectors. DNA-cationic polymer complexes are one of the most promising systems to find application in gene therapy. Hence, a complete insight of their biophysical characterization and binding energy profile is important in understanding the mechanism involved in nonviral gene therapy. In this investigation, the interaction between calf thymus DNA (ctDNA) and imidazolium-based poly(ionic liquids) (PILs) also known as polyelectrolytes with three different alkyl side chains (ethyl, butyl, and hexyl) in physiological conditions using various spectroscopic experiments with constant DNA concentration and varying polyelectrolyte concentrations is reported. UV-visible absorption, fluorescence quenching studies, gel electrophoresis, circular dichroism (CD), and Fourier transform infrared spectroscopy (FTIR) have confirmed the binding of polyelectrolytes with DNA. UV-vis absorption measurements and fluorescence quenching revealed that the binding between DNA and the polyelectrolyte is dominated by electrostatic interactions. Additionally, CD and FTIR results indicated that the DNA retained its B-form with minor perturbation in the phosphate backbone without significant change in the conformation of its base pairs. Preference for alkyl side chains (KPIL-Ethyl Br &lt; KPIL-Butyl Br &lt; KPIL-Hexyl Br) toward efficient binding between the polyelectrolyte and DNA was inferred from the binding and quenching constants calculated from the absorption and emission spectra, respectively. Further, in silico molecular docking studies not only validated the observed binding trend but also provided insight into the binding mode of the polyelectrolyte-DNA complex. (Chemical Equation Presented). © 2015 American Chemical Society.

Biomacromolecules

Biophysical Characterization and Molecular Docking Studies of Imidazolium Based Polyelectrolytes–DNA Complexes: Role of Hydrophobicity

Evaluation of imidazolium-based ionic liquids towards vermicidal activity: in vitro &amp; in silico studies

Poly(ionic liquids)(PILs) of the types poly(1-vinyl-3-alkyl imidazolium)X (where alkyl = ethyl, butyl &amp; pentyl; X = Br- or OH-) are synthesized and used for the preparation of stable silver, gold and nickel nanoparticles in solution. Studies pertaining to the dispersion of metal NP stabilized by PILs are discussed. The role of PILs is prominent as carriers towards reversible "solubility switch" of synthesized metal nanoparticles between aqueous and organic media by simple anionic metathesis. These PIL stabilized nanoparticles show great stability for longer period without agglomeration. At another role of employed PIL is the ability to tune the size of the metal NP, depending on the length of alkyl chains of PIL. UV-Visible, SEM and TEM techniques are used for the characterization and morphological study. PIL stabilized Ag NP shows very good antimicrobial activity at lower concentrations against Escherichia coli and Staphylococcus aureus. Ag NP are used in the catalytic reduction of aromatic nitro compounds with NaBH4 and that of Ni NP for hydrogen transfer reduction of acetophenone in quantitative yields. © 2014 Elsevier Ltd. All rights reserved.

European Polymer Journal

Poly(ionic liquids) as “smart” stabilizers for metal nanoparticles

RSC Adv.

1-Butylimidazole-derived ionic liquids: synthesis, characterisation and evaluation of their antibacterial, antifungal and anticancer activities

Veterinary Parasitology

Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the β-tubulin isotype 1 encoding gene in Haemonchus contortus

Journal	Data powered by TypesetRSC Advances
Publisher	Data powered by TypesetRoyal Society of Chemistry (RSC)
ISSN	20462069
Open Access	0