Quantifying comfort levels of lions within the Masai Mara National Reserve in Kenya is the main focus of this study. Its discourse delineates step by step the process of quantifying comfort levels of lions within the Mara. Resource-efficient measures for humans in the built environment have long been developed through the creation of passive zones and modulated ventilation. In an analogous manner, new procedures are being adapted for creating optimized microclimates in natural game reserves. This involves CFD (computational fluid dynamics)-inspired landscaping. It is seen that the predicted mean vote (PMV) values—measures of thermal comfort—exceed the expected comfortable ranges suitable for normal functioning of lions in the reserve. This calls for a detailed exploration on sustainable development of this sanctuary. The paper illustrates how modern tools in computational fluid dynamics can be used along with standard ecological models to ascertain the optimal extent of airflow, levels of hydration, and land use pattern changes affecting the prevailing microclimate. © 2019, ISB.