Many researchers have proposed different schemes of fiber reinforced polymer (FRP) wrapping to strengthen the Reinforced Concrete (RC) slab. However, the ideal system for FRP laminations is not readily available. A modular approach for strengthening of RC slabs (especially two-way slab) needs to be developed with respect to orientations and coverage area of FRP sheets in order to figure out the effective strengthening system. This paper describes the experimental study carried out to explore the effects of fiber reinforced polymers in different orientation and coverage areas to strengthen the structural members. Three systems of laminates have been used to strengthen the RC slabs using two types of fibers, namely carbon fiber reinforced polymer (CFRP) and glass fiber reinforced polymer (GFRP) composite. The systems are classified with respect to the orientation of FRP sheets such as edge, corner and center wrapping. Each system has three proportions of FRP coverage area in the order of 25%, 35%, and 45%. A set of fifty-four slabs were fabricated and tested at the rate of three specimens for each variant. The performance of the flexural strength of two-way RC slabs with different strengthening systems has been evaluated and compared. It shows that all the systems of strengthening are effectively enhancing the flexural strength of two-way RC slabs. The extent depends on the system orientation and coverage area of the FRP sheet. The higher-order performance is noticed when the FRP lamination has higher contact with the slab area and with closer proximity to the loaded area. © 2020 by authors, all rights reserved.