Automatic infusion system is an indispensable tool for the regulation of blood glucose level for diabetic patient in present and future. To date, all the commercially available models considers plasma and insulin concentration of the human body and so this paper reviews three different modes such as Continuous glucose monitoring (CGM) system, the drug estimation techniques (PI, FUZZY and MPC) and to find the optimal control strategy for insulin approximation. The fine-tuned numerical value of insulin provides solution for complex situation of diabetic patients. The robustness of the projected controller performance is evaluated under dynamic conditions such as delayed meals, variability in the type of meal and metabolic uncertainty case. Therefore, we review the validation results based on that the results the new improved combine control strategies to achieve the controlled and optimized insulin rate for persistent glucose control compare then the reviewed methods. The MATLAB simulation is used to evaluate the effectiveness of the proposed work and obtain the results based on the proposed values. © Research India Publications.