Alzheimer's disease (AD) is the most common neurodegenerative disease, caused by accumulation of abundant senile plaques and neurofibrillary tangles in certain brain regions. It is an irreversible and progressive disease that slowly destroys memory, thinking skills and, eventually the ability to perform simple day to day tasks. This project was to investigate the prevalence of Alzheimer's disease (AD) in Vellore and Chennai, India by conducting an epidemiological survey of 120 individuals from dementia club and old age homes and carrying out certain blood tests on patient's sample and comparing the results with the controls. Patient's cognitive function like orientation, registration, attention, calculation, recalling, and language were graded by minimal mental state examination (MMSE). Caregivers of the patients were interviewed to confirm the familial history and progression of the disease in the patients. The blood test results were correlated with that of MMSE. ESR, blood glucose and lithium ion concentrations were shown to be significant and presence of oxidative stress was seen in majority of the patients. Hence it is suggested that these factors can be quantified to confirm the presence or absence of disease. The in situ hybridization of blood samples of the patients yielded no result as there is no presence of amyloid-β protein, and can be avoided as a confirmatory test.