In this paper, we are concerned with a class of abstract second-order nonlocal Cauchy problem with impulsive conditions in Banach spaces. First, we study the existence of mild solutions for a class of second-order nonlocal Cauchy problem with impulsive conditions in Banach spaces on an interval [0,a]. Later, we study a couple of cases where we can establish the existence of global solutions for a class of abstract second-order nonlocal Cauchy problem with impulsive conditions in Banach spaces. We apply our theory to study the existence of solutions for impulsive partial differential equations. © 2017 Taylor & Francis.