Rapid growth in urbanization, industrialization and decrease in rainfall rates all over the world demands more fresh water for human use, industries and agriculture purpose. The novel desalination technologies for converting saline water into fresh water have more value and demand. Present work aim at evaluating the performance of an integrated air cooling and two stage desalination system using humidification dehumidification (HDH) technology experimentally by varying flow rate and temperature of saline water. The components of the proposed system are designed, developed and carried out experiments for different operating conditions to get optimum operating conditions. The plant consists of a solar water heater (SWH), two air preheaters, two humidifiers, two dehumidifiers with a normal and a vapour compression refrigeration water chiller. The influence of saline water temperature and flow rate on air temperature, desalination yield, recovery ratio, energy utilization factor (EUF), air cooling effect and coefficient of performance (COP) of the cooling system are studied. The experimental observations recommend higher saline water temperature with high flow rates to air preheaters and humidifiers, circulating and chilled water to dehumidifiers with lower possible temperatures. The integrated plant yields 240 W of cooling energy and a maximum fresh water of 2180 ml/h with 15 m3/h air flow at saline water temperature of 54.5°C with a flow rate of 200 LPH. Experimental results show a maximum EUF of 0.5 for the hybrid plant and 0.45 for conventional plant single stage plant. A maximum COP of 2.2 with a recovery ratio of 0.78 is observed from the experimental results. © 2019 Desalination Publications. All rights reserved.