Cocos nucifera is one of the most adaptable products which possess several protein fractions such as albumins, globulins, prolamines, glutelins 1 and 2 which were found and reported. Since C. nucifera was rich in nutritional value, it has wide medicinal applications. In this manuscript, we have reviewed on the anti-inflammatory, antioxidant, antimicrobial, antimalarial, leishmanicidal, and insecticidal activity. Also C. nucifera act as a low cost agricultural waste which was widely used in the preparation of nanoparticles: in this review, we have also focused on silver, gold, aluminum oxide, and doped nanoparticles like europium doped yttrium oxide nanoparticles. © 2015 Elsevier B.V.