During the homogeneous-heterogeneous autocatalytic chemical reaction in the dynamics of micropolar fluid, relaxation of heat transfer is inevitable; hence Cattaneo-Christov heat flux model is investigated in this report. In this study, radiative heat flux through an optically thick medium is treated as nonlinear due to the fact that thermal radiation at low heat energy is distinctly different from that of high heat energy, hence classical approach of using Taylor series for simplification is ignored and implicit differentiation is used leading to temperature parameter. Uniqueness of the present analysis is the consideration of cubic autocatalytic chemical reaction between the homogeneous bulk fluid and two species of catalyst at the wall. Application of similarity analysis enabled us to recast the flow equations into a set of coupled nonlinear ODEs. The resulting equations along with the appropriate conditions are solved computationally. Graphical illustrations of the effect of pertinent parameters on momentum, heat and mass boundary layers are presented and discussed. The concentration of the homogeneous bulk fluid with microstructures and catalyst at the surface decreases and increases with diffusion ratio, respectively. Buoyancy has a decreasing effect on temperature distribution. © 2020 Published by Shahid Chamran University of Ahvaz.