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Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice
T S Chandra, Murtaza N, Baboota R.K, Jagtap S, Singh D.P, Khare P, Sarma S.M, , Alagesan S, Chandra T.SShow More
Published in Cambridge University Press
2014
PMID: 25234097
Volume: 112
   
Issue: 9
Pages: 1447 - 1458
Abstract
Several epidemiological studies have shown that the consumption of finger millet (FM) alleviates diabetes-related complications. In the present study, the effect of finger millet whole grain (FM-WG) and bran (FM-BR) supplementation was evaluated in high-fat diet-fed LACA mice for 12 weeks. Mice were divided into four groups: control group fed a normal diet (10 % fat as energy); a group fed a high-fat diet; a group fed the same high-fat diet supplemented with FM-BR; a group fed the same high-fat diet supplemented with FM-WG. The inclusion of FM-BR at 10 % (w/w) in a high-fat diet had more beneficial effects than that of FM-WG. FM-BR supplementation prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression levels of several obesity-related genes, increased the abundance of beneficial gut bacteria ( Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents (P≤ 0·05). In conclusion, FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.
About the journal
JournalData powered by TypesetBritish Journal of Nutrition
PublisherData powered by TypesetCambridge University Press
ISSN00071145
Open AccessYes
Concepts (77)
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    ACETYL COENZYME A CARBOXYLASE
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    ADIPONECTIN
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    CD68 ANTIGEN
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    Glucose transporter 4
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    Immunoglobulin enhancer binding protein
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    INDUCIBLE NITRIC OXIDE SYNTHASE
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    Interleukin 6
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    Lipid
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    MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA
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    MONOCYTE CHEMOTACTIC PROTEIN 1
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    Tumor necrosis factor alpha
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    Glucose blood level
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    ACC GENE
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    ADAM8 GENE
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    ADIPOQ GENE
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    Animal experiment
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    Animal tissue
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    Article
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    Bacterium
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    BIFIDOBACTERIACEAE
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    BRAN
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    CD68 GENE
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    CECUM
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    Controlled study
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    Diet supplementation
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    Enterobacter
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    F4/80 GENE
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    FINGER MILLET
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    Gene
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    Gene expression
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    GLUT4 GENE
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    Grain
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    IL 6 GENE
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    Inflammation
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    INOS GENE
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    Intestine flora
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    Lactobacillus
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    LIPID DIET
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    MCP1 GENE
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    MIP 1 ALPHA GENE
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    Mouse
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    NF KAPPA B GENE
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    Nonhuman
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    Obesity
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    Oxidative stress
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    ROSEBURIA
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    Tnf alpha gene
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    Weight gain
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    Adipose tissue
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    Animal
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    BACTERIAL LOAD
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    Blood
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    ELEUSINE
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    Gene expression regulation
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    Genetics
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    Intestine
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    LIPID DIET
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    Liver
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    Metabolism
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    Microbiology
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    MUSCLE MITOCHONDRION
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    Nutrigenomics
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    Pancreas
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    Plant seed
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    Skeletal muscle
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    Animals
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    BACTERIAL LOAD
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    Blood glucose
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    DIET, HIGH-FAT
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    Dietary supplements
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    ELEUSINE
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    Intestines
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    Lipids
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    Mice
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    MITOCHONDRIA, MUSCLE
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    MUSCLE, SKELETAL
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    Seeds