Fluconazole, an inhibitor of cytochrome P450 enzyme is found hydrophobic with dissolution related problems and also fungistatic in action. On the account of few physico-chemical disadvantages, we worked on a novel cinnamon oil based nanoemulsion drug delivery system. The drug-loaded formulation used cinnamon oil, tween 80 and water at a ratio of 6:18:76 v/v and was checked for various parameter of the internal system including conductivity, droplet size and polydispersity index. The surfactant concentration was reduced to a great extent using sonicator as high energy method at a laboratory scale; that would help in the reduction of gastrointestinal irritation. Also sonication helps in the breakdown of coarse emulsion to fine droplets (nanoemulsion). The particle size reduction to about 55 nm as determined by dynamic light scattering technique would enable easy permeation through capillaries. Thus we propose that the formulated system would serve as excellent oral drug delivery system for fluconazole.