The petroleum ether, benzene, chloroform, acetone and ethanol extract of Thevetia neriifolia (Apocynaceae) leafs were investigated for free radical scavenging properties. The antioxidant activities of extracts were investigated using 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging assay. Butylated hydroxytoluene and L-ascorbic acid were employed as a positive control. All extracts showed DPPH radical scavenging activities, but among them petroleum ether extract shows maximum activity as compared to other extracts.