The current study challenges the multi-objective optimization of electric discharge machining (EDM) parameters. EDM is used for creating profiles by machining of workpiece that are difficult to machine by conventional method. In the current work four responses such as material removal rate (production rate), tool wear rate, surface roughness (quality) and circularity (profile) are collectively investigated with varying controlling parameters. The human decision for best combination of controlling parameters for highest performance has uncertainties, which results in inferior solution. The multiple responses along with uncertainties and impreciseness can be addressed by combining a neuro-fuzzy system with particle swarm optimization (PSO). To illustrate the superiority of the proposed approach a set of experiment have been conducted in EDM process using AISI D2 tool steel as workpiece and brass tool. The experimental plan was made according to the Box-Behnken response surface methodology design with four process parameters namely discharge current, pulse-on-time, duty factor, and flushing pressure. The four response parameters such as material removal rate, tool wear rate, surface roughness, and circularity of machined components were optimized simultaneously. One unique Multi-response Performance Characteristic Index was obtained by combining the four responses using the proposed neuro-fuzzy technique. A regression model was developed on single response and optimized by PSO to obtain the optimal parameter setting. An experiment was conducted on optimal parameter to test the optimum performance. It is observed that the EDM responses were affected significantly by discharge current and pulse-on-time. The increase in pulse-on-time leads to larger surface cracks and more micro-pores on the machined surface.