Many analog design techniques and methodology have been devised for better performance of amplifier. Now a day operational amplifier is the backbone of the analog and mixed signal device. It is fundamental block of the many design circuit that utilize high gain, high bandwidth, fast settling time. Op amp is one of the basic building block of analog circuit which has wide range of application such as biomedical application, ADC converter, switched capacitor filter. This paper presents the novel structure of folded cascode amplifier for enhancing the gain. In this quadruple-recycling folded cascode (QRFC) operational transconductance (OTA) amplifier is used to improve the performance over the conventional folded cascode (FC), double recycle, and improved recycle folded structures. The proposed structure uses positive feedback, cross coupled transistors which significantly improve its unity gain bandwidth, DC gain and slew rate as compared to others OTA structures. Circuit level simulations and analysis results done with 180nm CMOS technology validate the improved gain of 95dB for single stage fully differential mode and enhance bandwidth of 185.2 MHz. © 2006-2017 Asian Research Publishing Network (ARPN).