Abstract Recent studies confrm foral waste as one of the crucial and most neglected municipal solid waste (MSW) in India due to its traditional mode of disposal into rivers and surroundings, which eventually afects the environment and ultimately leads to health issues. Floral waste is considered as one of the crucial and most neglected municipal solid waste (MSW) in India due to its traditional mode of disposal into rivers and surroundings, which eventually afects the environment and ultimately lead to health issues. Our study aims to investigate the methanolic extracts of Ixora coccinea waste (Rubiaceae), Chrysanthemum morifolium waste (Asteraceae) and Floral waste (contains several foral debris) for characterisation for phytochemical screening by using GC–MS and FTIR, statistical optimisation (Lipinski’s Rule of Five), physicochemical (ADMET) and in-silico studies. Gas Chromatography–Mass Spectrometry analysis confrmed 26 volatile compounds. Fourier Transform Infra-Red Spectroscopy analysis provides characteristic functional groups. Subsequently, statistical optimisation analysis was performed using Lipinski’s analysis. Furthermore, ADMET analysis confrms the physicochemical properties of these bioactive compounds. In addition, using one-way ANOVA, which provides p≤0.05, indicates signifcance. Phytochemical studies confrm all phytochemicals in the foral waste except glycoside. In the quantitative estimation of phenols and favonoids, foral waste had the highest Total Phenolic Content, and Ixora coccinea waste had the highest Total Flavonoid Content with 19.07 mg GAE/g and 10 mg QE/g DE, respectively. The interactions of the three identifed phytocompounds of Floral waste were analysed for their medicinal properties using in-silico molecular docking studies. Results show that 12, oleanen-3-yl acetate (3-alpha), might have a maximum binding score followed by eicosane-7 hexyl and tetracosane. Finally, we focused on foral waste debris degradation by using the baiting technique. T