Header menu link for other important links
Hantzsch 1,4-dihydropyridine esters and analogs: candidates for generating reproducible one-dimensional packing motifs
Rathore R.S, Reddy B.P, Ragavan R.V, Narasimhamurthy T.,
Published in International Union of Crystallography (IUCr)
PMID: 19461148
Volume: 65
Issue: 3
Pages: 375 - 381
Examination of the symmetric Hantzsch 1,4-dihydropyridine ester derivatives of the prototypical nifedipine molecule indicates the tendency of this class of molecule to form a common packing motif. Crystal structure analysis of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic diesters and analogs reveals that they form extended chains, characterized as the C(6) packing motif, via intermolecular (amine) N—H...O=C (C3,C5 carbonyl) hydrogen bonds. In addition, all the prepared derivatives also satisfy the basic structural requirements for their high binding efficiency to the receptor. The reproducible C (6) packing motif observed among these compounds has a use in the design of solid-state materials.
About the journal
JournalActa Crystallographica Section B Structural Science
PublisherInternational Union of Crystallography (IUCr)
Open Access0