Dynamics of blood containing gold nanoparticles on a syringe and other objects with a nonuniform thickness is of importance to experts in the industry. This study presents the significance of partial slip (i.e. combination of linear stretching and velocity gradient) and buoyancy on the boundary layer flow of blood-gold Carreau nanofluid over an upper horizontal surface of a paraboloid of revolution (uhspr). In this report, the viscosity of the Carreau fluid corresponding to an infinite shear-rate is assumed as zero, meanwhile, the viscosity corresponding to zero shear-rate, density, thermal conductivity, and heat capacity were assumed to vary with the volume fraction of nanoparticles. The governing equation that models the transport phenomenon were non-dimensionalized and parameterized using suitable similarity variables and solved numerically using classical Runge–Kutta method with shooting techniques and MATLAB bvp4c package for validation. The results show that temperature distribution across the flow decreases more significantly with buoyancy-related parameter when the influence of partial slip was maximized. Maximum velocity of the flow is ascertained at larger values of partial slip and buoyancy parameters. At smaller values of Deborah number and large values of volume fraction, maximum local skin friction coefficient, and local heat transfer rate are ascertained. © 2018 Wiley Periodicals, Inc.