<p>Objective: To analyze the hepatoprotective effect of the Crossandra infundibuliformis. Methods: Hepatotoxicity was induced by carbon tetrachloride. Petroleum ether extract of dried leaves was administrated to mice for 7 days. The hepatoprotective effect of petroleum ether extract was evaluated by the assay of liver function biochemical parameters. Results: The result clearly indicates that petroleum ether extract showed significant hepatoprotection when compared with standard Silumarin. Conclusions: The petroleum ether extract of the leaves of Crossandra infundibuliformis possess significant acute hepatoprotective activity. Thus further investigation on this species would bring a promising drug for liver disorders. © 2010 Hainan Medical College.</p>

Madhumitha G

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Mary Saral A

Senthilkumar B

Sivaraj A.

Fulltext

<p>Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.</p>

<p>VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;<strong>VIT</strong>, Vellore as an&nbsp;<strong>Institution of Eminence</strong>. This has allowed VIT to take independent quality initiatives and move up in world ranking.</p>

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Hepatoprotective potential of petroleum ether leaf extract of Crossandra infundibuliformis on CCl4 induced liver toxicity in albino mice.

Asian Pacific Journal of Tropical Medicine

Dihydroquinazolinones is an important core structure reported with a wide variety of pharmacological activities. They are capable of undergoing various transformations because of its reactivity towards various reagents. The synthetic strategies for the functionalization and derivatization of the nucleus were explained. The diversified pharmacological actions of this moiety were illustrated through various biochemical pathways. The structural-activity relationship study of dihydroquinazolinones anticipated the relationship between the various substituents and its role in the pharmacological action. The main objective of this review is to summarize the importance of dihydroquinazolinones in the field of chemical biology.

European Journal of Medicinal Chemistry

Synthetic strategy with representation on mechanistic pathway for the therapeutic applications of dihydroquinazolinones

Integration of green chemistry principles to nanotechnology is one of the key issues in nanoscience research. Biological methods were used to synthesize metal and metal oxide nanoparticles of specific shape and size since they enhance the properties of nanoparticles in greener route. Plant-mediated methods devoid the use of toxic chemicals in the synthetic protocols which has adverse effects on the environment. Owing to the rich biodiversity of plants and their potential secondary constituents, plants and plant parts have gained attention in recent years as medium for nanoparticles' synthesis. In this review, we present the current status of nanoparticles synthesis using devastated crops.

Journal of Nanomaterials

Devastated Crops: Multifunctional Efficacy for the Production of Nanoparticles

Objective: To determine the antioxidant activity, total phenolic and flavonoid content of Petroleum ether extract (PE), Dichloromethane extract (DCM), Ethanol extract (ET) and aqueous extract (AQ) of henna seeds. Methods: Total antioxidant assay (phosphomolybenum method), DPPH radical scavenging assay, reducing power assay and lipid peroxidation inhibition assay were used to ascertain the potential of seeds as an antioxidant. Results: In all the assays carried out ET showed a greater potential to scavenge DPPH radical, reduce MO (VI) to MO (V) complex and Fe (III) to Fe (II) and to inhibit lipid peroxidation. The IC 50 of ET was far greater than that of the standard, ascorbic acid (AS) in the lipid peroxidation assay. The activity of AQ was lesser when compared with that of ET but greater than PE and DCM. The amount of phenolics and flavonoids were present in higher amounts in ET followed by AQ. Trace amounts of phenolics were detected in PE and DCM, but the amount of flavonoids were below the detection level. The study showed that the antioxidant activity and the concentrations of phenolics and flavonoids are proportionate to each other. Conclusions: Ethanolic extract of henna seeds are efficient antioxidants, which can be utilized for further isolation of active compounds and pharmaceutical applications. {\textcopyright} 2011 Hainan Medical College.

Free radical scavenging and reducing power of Lawsonia inermis L. seeds

<h3>Objective</h3><p>To investigate the phytochemical, antibacterial, antifungal and anticandidal activity of successive extracts of <i>Crossandra infundibuliformis</i> (Acanthaceae) leaves.</p><h3>Methods</h3><p>Preliminary screening on the presence of alkaloids, saponins, phytosterols, phenolic compounds, flavanoids, tannins, carbohydrates, terpenoids, oils and fats were carried out by phytochemical analysis. The antibacterial, antifungal and anticandidal activities were done by agar well diffusion technique.</p><h3>Results</h3><p>The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0 μg/mL. In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250 μg/mL.</p><h3>Conclusions</h3><p>These findings demonstrate that the leaf extracts of <i>C. infundibuliformis</i> presents excellent antimicrobial activities and thus have great potential as a source for natural health care products.</p>

Preliminary phytochemical analysis, antibacterial, antifungal and anticandidal activities of successive extracts of Crossandra infundibuliformis

Journal of Ethnopharmacology

Anti-inflammatory activity of roots of Ecbolium viride (Forsk) Merrill

Food Chemistry

Hepatoprotective effect of the root extract of Decalepis hamiltonii against carbon tetrachloride-induced oxidative stress in rats

Food and Chemical Toxicology

Hepatoprotective activity of Amaranthus spinosus in experimental animals

Hepatoprotective effect of Hypericum japonicum extract and its fractions

Hepatoprotective potential of petroleum ether leaf extract of Crossandra infundibuliformis on CCl4 induced liver toxicity in albino mice

Journal	Asian Pacific Journal of Tropical Medicine
Publisher	Medknow
ISSN	1995-7645
Open Access	Yes