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Hybridization and reaction-based fluorogenic nucleic acid probes
, B. Flottmann, M. Heilemann, A. Mokhir
Published in
PMID: 22911172
Volume: 48
Issue: 77
Pages: 9664 - 9666
We developed fluorogenic probes, which are photoactivated in the presence of specific nucleic acid templates with the release of fluorescent dyes. This templated reaction can be used to target specific nucleic acids in complex mixtures. We further demonstrate that this reaction can be monitored by single-molecule fluorescence imaging. © 2012 The Royal Society of Chemistry.
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JournalChemical Communications