The present investigation deals with Taylor dispersion of reactive species in Casson liquid in an oscillatory flow because of the pulsatile pressure gradient. The solute is considered to be chemically active at the boundary and also participate a first order reaction within the bulk flow. To evaluate transport coefficients, Aris-Barton moment technique is considered. The solute transport process is discoursed in detailed with respect to yield stress, chemical reaction parameter, Womersly number etc. The study reveals that both wall absorption and bulk flow reaction have a significant response on dispersion phenomena. Both the chemical reactions agree to diminish the negative exchange coefficient and the apparent dispersion coefficient, however, increases the negative convection coefficient. The negative exchange coefficient is independent of yield stress but a significant variation is observed due to yield stress in the cases of negative convection coefficient and the apparent dispersion coefficient. The axial distribution of mean concentration is approximated by using the Hermite polynomial representation of central moments as a function of reaction rate parameters, wall absorbing parameter, yield stress etc. The present article may be useful for the studies related to physiological blood flow analysis. © 2019 International Information and Engineering Technology Association. All rights reserved.