Ravishankar B

Department of Hotel & Tourism Management

School of Hotel & Tourism Management (HOT)

Vellore Campus

Arvind d thakkar

Hemanth raj

Debarshi chakrabarti

N saravanan

Bhaskaran muthuvelan

Arun balakrishnan

Muralidhara padigaru

Fulltext

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Biomarkers in Cancer

Biomarker Insights

High Expression of Three-Gene Signature Improves Prediction of Relapse-Free Survival in Estrogen Receptor-Positive and Node-Positive Breast Tumors

Microarray technology can be used to study the molecular mechanisms of new chemical entities with the aim to develop effective therapeutics. 7-Hydroxyfrullanolide (7HF) is a sesquiterpene lactone that was found to be efficacious in multiple animal models of inflammation by suppression of pro-inflammatory cytokines; however, its molecular mechanism of action remains unclear. We investigated the effects of 7HF on lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells using microarray-based gene expression studies and explored the molecular targets affected. Gene expression profiles and pathway analysis revealed that 7HF potently suppressed multiple inflammatory pathways induced by LPS. More importantly, 7HF was found to inhibit NF-κB related transcripts. These transcripts were further validated using freshly isolated synovial cells from rheumatoid arthritis patients, thus clinically validating our findings. Cell-based imaging and subsequent Western blot analysis demonstrated that 7HF inhibited the translocation of NF-κB into the nucleus by directly inhibiting the phosphorylation of IKK-β. Since the transcription of adhesion molecules is regulated by NF-κB, further investigation showed that 7HF dose-dependently suppressed ICAM-1, VCAM-1 and E-selectin expression on LPS-stimulated endothelial cells as well as inhibited the adhesion of monocytes to LPS-stimulated endothelial cells. Taken together, our results reveal that 7HF possesses NF-κB inhibitory potential and suggest a likely molecular mechanism of its anti-inflammatory activity. © 2010 Elsevier B.V.

European Journal of Pharmacology

NF-κB-mediated anti-inflammatory activity of the sesquiterpene lactone 7-hydroxyfrullanolide

Biochemical and Biophysical Research Communications

Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells

Journal of Applied Toxicology

Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood

European Journal of Pharmaceutical Sciences

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

Proceedings of the National Academy of Sciences

Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B

Journal of Clinical Oncology

Molecular classification based on only four genes identifies basal-like subtypes in high-risk breast cancer patients

Breast Cancer Research

Recent breast cancer trends among Asian/Pacific Islander, Hispanic, and African-American women in the US: changes by tumor subtype

Cancer Research

PC-1/PrLZ Contributes to Malignant Progression in Prostate Cancer

Identification of Gene Expression Signature in Estrogen Receptor Positive Breast Carcinoma

Journal	Data powered by TypesetBiomarkers in Cancer
Publisher	Data powered by TypesetSAGE Publications
ISSN	1179-299X
Open Access	Yes