With the passage of time, clinically significant antibiotic resistance has evolved globally against almost every antibiotic deployed. Yet the development of new classes of antibiotics has lagged far behind our growing need for such new and effective drugs. Antimicrobial peptides (AMPs) have emerged as novel therapeutics hailed for their virucidal, bactericidal and immunomodulatory properties. However, the process of optimizing antimicrobial peptide stability using large peptide libraries is both tedious and expensive. The intent of this study is to analyze computationally the stability of Anti-viral peptides (AVPs) and to discover a potential candidate from a pool of AVPs for therapeutic use. Consequently we highlighted that the AVP human α-defensin-5 (HD5) appears advantageous over the other AVPs used in the study with respect to stability and may provide a convenient platform for the development of a suitable anti-viral therapeutic peptide.