The aim of this article is to investigate the current trends and impact of nanotechnology in induced pluripotent stem cells (iPSCs)-driven tissue engineering and regenerative medicine. The iPSCs are considered as one of the potential cell sources for tissue engineering applications due to their self-renewal and differentiation abilities. However, the key to realize their full potential in tissue engineering requires a deep understanding of the iPSCs biology and their cellular interaction with three-dimensional (3D) scaffolds, which support and regulate the cellular growth and function, in conjunction with signaling molecules. At the cellular and molecular level, nano-scale features play an important role in controlling cell behavior and other physiological functions of iPSCs. Therefore, nanomaterial-based scaffolds have tremendous impact in iPSCs-driven tissue engineering and regenerative medicine. Nanomaterials have been proved to serve as a scaffolding system for tissue engineering, as a carrier system for delivery of cells and genes, and as a marker system for imaging and tracking of iPSCs. In this article, we therefore discuss briefly the impact of nanotechnology on cell behavior and iPSCs-driven tissue engineering and regenerative medicine applications with their recent challenges and advancements.