Tuning of proportional integral and derivative (PID) Controllers for stable and unstable second order plus time delay systems (SOPTD), based on Model Driven Two Degree of Freedom PID (MDTDOF PID) and Internal model controller (IMC) are proposed in this paper. Due to inherent disadvantages of conventional control techniques, model based control techniques are employed. MDTDOF PID is developed to control and maintain a constant temperature environment in Thermo Electric Cooler (TEC) and IMC PID controller is designed to control unstable Jacketed Continuous Stirred Tank Reactor (CSTR). The performance of the proposed controllers is compared with the conventional Ziegler-Nichols (Z-N) method. The paper also presents the simulation results for both stable and unstable systems with transfer function models to show the effectiveness and advantages of proposed methods. © 2014 IEEE.