Lennox-Gas taut Syndrome (LGS) is commonly characterized by a triad of features including multiple seizure types, intellectual disability or regression. The long-term prognosis for LGS is generally poor due to uncontrolled seizures. LGS type of seizures is epilepsy which is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the seizures and the lungs suffer a lack in oxygen content to a considerable extent. These results in prolonged vibrations and loses of nervous control. As a neuro-lung protective strategy, a novel attempt has been made to enrich both seizures and lungs with oxygen content through the support of perfluorodecalin (an excellent oxygen carrier) C10F18(PFD) along with an enhancement in the antiepileptic activity by the two chosen antiepileptic drugs (AEDs) Carbamazepine (CBZ) and Benzodiazepine (BDZ). Emulsions of Perfluorodecalin (PFD) were prepared by sonication process with combination of nonionic emulsifier, Lecithin (L-α-phosphatidylcholine) as a surfactant in aqueous phase medium. These emulsions were mixed with Carbamazepine (CBZ) and Benzodiazepine (BDZ) drugs maintained at a temperature of about −20 ºC to 20 ºC and were set to slow evaporation process. The samples were subjected to Optical microscope, Transmission Electron Microscopy (TEM) and Scanning Electron Microscope (SEM)-EDS. The study reveals the co-existence of Fluorine and Drug ensuring the Oxygen enrichment. Morphology of TEM, Optical microscopic images and the particle diameter estimated through Image_J confirms this analysis. © 2016 American Scientific Publishers. All rights reserved.