An attempt has been made to develop a corrosion resistant anodized aluminium film using a special sealing free from rare earths based on Cellulose acetate phthalate (CAP) and Sulfamethoxazole (SM) drugs in a quantitative way.The corrosion resistance of the anodized aluminium surfaces was enhanced by the above compounds in the presence of anionic surfactant. The performance of the sealant film was screened through potentiodynamic polarization and A.C impedance analysis. The calculations of quantum mechanical descriptors such as the localization of frontier molecular orbital's, EHOMO, ELUMO, energy gap (>E) and dipole moment (μ), were used to substantiate the effective adsorption of the blended drugs on anodized surfaces. AFM studies justified the formation of protective layer on anodized metal.