The present study describes the in-silico molecular docking of three compounds (ligands) i) Cyclopentanepropanoic acid, 3,5-bis(acetyloxy)-2-[3- (methoxyimino) octyl], methyl ester (C22H37NO 7), ii) 5-Azidomethyl-3-(2-ethoxycarbonyl-ethyl)-4-ethoxy- carbonylmethyl-1H-pyrrole-2-carboxylic acid (C17H24N 4O8) and iii) Akuammilan-16-carboxylic acid, 17-(acetyloxy)-10-methoxy, methyl ester (C24H28N 2O5) extracted from Streptomyces sp.VITSTK7 with interleukin-13, one of the key pro-inflammatory cytokine of asthma, and the PDB ID is 1IJZ. Patch dock online tool was used to dock these three compounds with interleukin-13. All the three ligands C22H37NO7 C17H24N4O8 and C24H 28N2O5 showed the binding energy of -159.59, -208.41 and -93.56 kcal/mol respectively. Hence, it could be used as a drug for asthma.