Feeding dehydroascorbic acid (DHA) to rats produced hyperoxaluria, hypercalcuria and increased retention of oxalate in kidney. Increased oxalate binding in kidney was observed in DHA fed rats and it was found to be associated with increased lipid peroxidation (LPO) reaction and decreased activity of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase and glutathione-s-transferase (GST) and decreased levels of oxygen free radical scavengers glutathione (GSH) and vitamin E. © 1993 Pergamon Press Ltd.