Peristaltic transport of Newtonian nanofluid in an inclined annulus terms of radii regarding peristalsis and elasticity. It is noticed that with an increase in amplitude ratio, flux is getting enhanced in the absence of nanoparticles when compared with viscous fluid with nanoparticles. Our results reduce to the corresponding ones of Rubinow and Keller as a special case for the viscous flow in an elastic tube. The effect of various emerging parameters bounded by two concentric cylinders is studied under the assumption of long wavelength and dominance of viscous effects over inertial effects. The outer cylinder is elastic in nature and has a sinusoidal wave traveling down in its wall, whereas the inner cylinder is rigid. Analytical solutions have been established for velocity, flux, pressure rise, temperature distribution, and nanoparticle concentration. The flux, pressure rise, and frictional forces have been obtained in on the flow characteristic are presented and discussed. Obtained results may be useful in understanding the behavior of peristaltic transport of blood flow in small blood vessels and blood flow through elastic arteries. © 2020 Wiley Periodicals LLC