The velocity slip effects on MHD peristaltic pumping of a Prandtl fluid in a non-uniform channel is investigated under the assumptions of long wavelength and low Reynolds number. A regular perturbation technique is employed to solve the non-linear system of equations. The velocity field, the axial pressure gradient, the pressure rise and the frictional force over one cycle of the wave length are obtained. The results are discussed graphically. It is noticed that the amplitude of the pressure gradient decreases with increasing the velocity slip parameter further it increases with increasing the Hartmann number.