Get all the updates for this publication
Journal Article
Inhibitory effect of apocarotenoids on the activity of tyrosinase: Multi-spectroscopic and docking studiesPublished in Elsevier BV
2016
PMID: 26187443
Volume: 121
Issue: 1
Pages: 13 - 20
In this present study, the inhibitory mechanism of three selected apocarotenoids (bixin, norbixin and crocin) on the diphenolase activity of tyrosinase has been investigated. The preliminary screening results indicated that apocarotenoids inhibited tyrosinase activity in a dose-dependent manner. Kinetic analysis revealed that apocarotenoids reversibly inhibited tyrosinase activity. Analysis of fluorescence spectra showed that apocarotenoids quenched the intrinsic fluorescence intensity of the tyrosinase. Further, molecular docking results implied that apocarotenoids were allosterically bound to tyrosinase through hydrophobic interactions. The results of the in vitro studies suggested that higher concentrations of bixin and norbixin inhibited tyrosinase activity in B16F0 melanoma cells. Our results suggested that apocarotenoids could form the basis for the design of novel tyrosinase inhibitors. © 2015 The Society for Biotechnology, Japan.
Content may be subject to copyright.
About the journal
| Journal | Data powered by TypesetJournal of Bioscience and Bioengineering |
|---|---|
| Publisher | Data powered by TypesetElsevier BV |
| ISSN | 1389-1723 |
| Open Access | No |
Authors (3)
Gopalakrishnan T- A Detailed Research on Detection of Polycystic Ovary Syndrome from Ultrasound Images of Ovaries
- Synthesis, crystal structure, DNA binding and molecular docking studies on new copper(II) salicylate [Cu(DTBSA)2(2,2′-bpy)](dmf)
- Functionality study of santalin as tyrosinase inhibitor: A potential depigmentation agent
- Inhibitory effect of brazilein on tyrosinase and melanin synthesis: Kinetics and in silico approach
Palanisami N- Synthesis, spectral characterization, and single crystal X-ray structures of a series of manganese-2,2′-bipyridine complexes derived from substituted aromatic carboxylic acids
- Non-covalently aggregated zinc and cadmium complexes derived from substituted aromatic carboxylic acids: Synthesis, spectroscopy, and structural studies
- Synthesis, crystal structure, DNA binding and molecular docking studies on new copper(II) salicylate [Cu(DTBSA)2(2,2′-bpy)](dmf)
- Correction: Non-covalent polyhedral oligomeric silsesquioxane-polyoxometalates as inorganic–organic–inorganic hybrid materials for visible-light photocatalytic splitting of water
Siva R- An endophytic fungus, Gibberella moniliformis from Lawsonia inermis L. produces lawsone, an orange-red pigment
- Camptothecin-producing endophytic bacteria from Pyrenacantha volubilis Hook. (Icacinaceae): A possible role of a plasmid in the production of camptothecin
- Exploring the Fences Pertaining to Non Espousal of Traditional Knowledge Based Medicines at Shervaroy Hills, Eastern Ghats, India
- Induction of somatic embryogenesis and organogenesis in Oldenlandia umbellata L., a dye-yielding medicinal plant
