Wireless sensor Network (WSN) is an emerging technology has significant applications in several important fields like military, agriculture, healthcare, environmental, artificial intelligence and research. All these applications demands high quality data transmission from resource constraint WSNs. But interference is one of the severe problem in WSN which can degrade the quality data transmission. Various interference minimization techniques have been proposed but not results the expected degree of quality enhancement in WSNs. This research paper investigates various types of heterogeneous wireless sensor networks (HTWSN) deployment techniques, interference and its effects, existing interference minimization techniques with limitations. We propose interference minimization (IM) protocol for heterogeneous wireless sensor networks. IM protocol can efficiently minimize the interference and enhance the quality data transmission in WSN. © Springer International Publishing Switzerland 2016.