Proteomics is the extensive investigation of proteins which has empowered the recognizable proof of consistently expanding quantities of protein. Proteins are necessary part of living life form, with numerous capacities. The proteome is the complete arrangement of proteins that are created or altered by a life form or framework of the organism. Proteome fluctuates with time and unambiguous prerequisites, or stresses, that a cell or organism experiences. Proteomics is an interdisciplinary area that has derived from the hereditary data of different genome ventures. Much proteomics information is gathered with the assistance of high throughput techniques, for example, mass spectrometry and microarray. It would regularly take weeks or months to analyze the information and perform examinations by hand. Therefore, scholars and scientific experts are teaming up with computer science researchers and mathematicians to make projects and pipeline to computationally examine the protein information. Utilizing bioinformatics procedures, scientists are prepared to do quicker investigation and protein information storing. The goal of this paper is to brief about the review of machine learning procedures and its application in the field of proteomics. © 2019 Elsevier Ltd