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Iron Catalyzed Synthesis of Pyrimidines Under Air
Rakesh Mondal, Suman Sinha, Siuli Das, , Nanda Paul D.
Published in
Volume: 362
Issue: 3
Pages: 594 - 600
Herein we report an iron-catalyzed multicomponent dehydrogenative functionalization of alcohols to pyrimidines under atmospheric conditions. Using a well-defined Fe(II)-complex featuring redox noninnocent 2-phenylazo-(1,10-phenanthroline) ligand, as a catalyst, a wide array of 2,4,6-trisubstituted pyrimidines were prepared via dehydrogenative coupling of primary and secondary alcohols with amidines under air at 100 °C. A few control experiments were carried out to understand and unveil the plausible reaction mechanism. (Figure presented.).
About the journal
JournalAdvanced Synthesis and Catalysis