Raj Kumar V

VIT Business School

Vellore Campus

Guha G

Kumar R.A.

<p>Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.</p>

<p>VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;<strong>VIT</strong>, Vellore as an&nbsp;<strong>Institution of Eminence</strong>. This has allowed VIT to take independent quality initiatives and move up in world ranking.</p>

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VIT University

Isolation and bioactivity evaluation of two metabolites from the methanolic extract of Oroxylum indicum stem bark

Asian Pacific Journal of Tropical Biomedicine

<h3>Background</h3><p>4-nitroquinoline 1-oxide (4-NQO) is a mutagen known to be responsible for causing cancer by generating oxidative stress in humans. <i>Oroxylum indicum</i> (L.) possesses various bioactive compounds with antioxidant properties. In this connection, the present study aims to analyze the alleviation of 4-NQO induced oxidative stress in albino Wistar rats using <i>O. indicum</i> (L.) leaf extract.</p><h3>Methods</h3><p><i>O. indicum</i> (L.) belonging to the family Bignoniaceae, has anticancer and anti-inflammatory properties. In this study, we observed severe oxidative stress in 4-NQO induced albino Wistar rats when compared to untreated control. Alleviation of this condition was seen after the oral administration of <i>O. indicum</i> (L.) leaf extract at 50, 100, and 200&nbsp;mg/kg body weight.</p><h3>Results</h3><p>4-NQO (50&nbsp;ppm) administration in drinking water resulted in the generation of reactive oxygen species (ROS) leading to cellular damage, lipid peroxidation and imbalance in antioxidant status. Administration of <i>O. indicum</i> (L.) leaf extract has alleviated the level of 4-NQO induced oxidative stress by increasing the antioxidant status and decreasing the elevation of liver markers in serum.</p><h3>Conclusions</h3><p>Results clearly suggest that <i>O. indicum</i> (L.) leaf extract when administered orally in a dose dependent manner has the ability to overcome the oxidative stress induced by 4-NQO with hepatoprotective and lipid protective properties.</p>

Fulltext

BMC Complementary and Alternative Medicine

Alleviation of 4-nitroquinoline 1-oxide induced oxidative stress by Oroxylum indicum (L.) leaf extract in albino Wistar rats

<p>Annona muricata is a naturally occurring edible plant with wide array of therapeutic potentials. In India, it has a long history of traditional use in treating various ailments. The present investigation was carried out to characterize the phytochemicals present in the methanolic and aqueous leaf extracts of A. muricata, followed by validation of its radical scavenging and DNA protection activities. The extracts were also analyzed for its total phenolic contents and subjected to HPLC analysis to determine its active metabolites. The radical scavenging activities were premeditated by various complementary assays (DRSA, FRAP and HRSA). Further, its DNA protection efficacy against H2O2 induced toxicity was evaluated using pBR322 plasmid DNA. The results revealed that the extracts were highly rich in various phytochemicals including luteolin, homoorientin, tangeretin, quercetin, daidzein, epicatechin gallate, emodin and coumaric acid. Both the extracts showed significant (p &lt; 0.05) radical scavenging activities, while methanolic extract demonstrated improved protection against H2O2-induced DNA damage when compared to aqueous extract. A strong positive correlation was observed for the estimated total phenolic contents and radical scavenging potentials of the extracts. Further HPLC analysis of the phyto-constituents of the extracts provides a sound scientific basis for compound isolation. © 2014, Association of Food Scientists &amp; Technologists (India).</p>

Journal of Food Science and Technology

Antioxidant, DNA protective efficacy and HPLC analysis of Annona muricata (soursop) extracts

Food and Chemical Toxicology

Antioxidant and anti-neoplastic activities of Picrorhiza kurroa extracts

Hexavalent chromium Cr(VI) is a very strong oxidant which consequently causes high cytotoxicity through oxidative stress. Prevention of Cr(VI)-induced cellular damage has been sought in this study in aqueous and methanolic extracts ofLawsonia inermis Linn. (Lythraceae), commonly known asHenna. The extracts showed significant (P< .05) potential in scavenging free radicals (DPPH• and ABTS•+) and Fe3+, and in inhibiting lipid peroxidation. DNA damage caused by exposure of pBR322 to Cr(VI)-UV is markedly inhibited by both extracts in varying degrees. A distinct decline in Cr(VI)-induced cytotoxicity was noticed in MDA-MB-435S (human breast carcinoma) cells with an increase in dosage of both extracts individually. Furthermore, both extracts proved to contain a high content of phenolic compounds which were found to have a strong and significant (P< .05) positive correlation to the radical scavenging potential, lipid peroxidation inhibition capacity and cyto-protective efficiency against Cr(VI)-induced oxidative cellular damage. HPLC analysis identified some of the major phenolic compounds in both extracts, which might be responsible for the antioxidant potential and the properties of DNA and cyto-protection. This study contributes to the search for natural resources that might yield potent therapeutic drugs against Cr(VI)-induced oxidative cell damage.

Evidence-Based Complementary and Alternative Medicine

Antioxidant Activity ofLawsonia inermisExtracts Inhibits Chromium(VI)-Induced Cellular and DNA Toxicity

Molecules

Bioassay-Directed Isolation of Active Compounds with Antiyeast Activity from a Cassia fistula Seed Extract

Malaria Research and Treatment

In VitroAntiplasmodial Activity and Cytotoxicity of Extracts of Selected Medicinal Plants Used by Traditional Healers of Western Cameroon

Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts

Journal	Asian Pacific Journal of Tropical Biomedicine
Publisher	Medknow
ISSN	2221-1691
Open Access	0