The present work focuses on the development of non-invasive blood glucose measurement device to revolutionize diabetes management and reduce severe complications associated with it. A low cost, painless and non-invasive blood glucose measurement system is designed using near-infrared (NIR) LED and four photodiodes for the purpose. NIR light emitted by LED passes through the skin and is detected by photodiodes after attenuation. The detector converts the attenuated light into a voltage signal. The interference due to background noise generated by human skin is removed by taking floating or internal reference. The voltage signal obtained from the photodiodes is calibrated using Levenberg–Marquardt-based Artificial Neural Network to obtain the glucose concentration. The accuracy of proposed prototype was examined by comparing non-invasively predicted data with invasively measured reference data. It is observed that all measurements lie in A and B zones of Clarke error grid and thus clinically accurate. © 2018 IETE.

Rani C

Department of Electrical Engineering

School of Electrical Engineering

Vellore Campus

Bhaskar Mohan Murari

Department of Sensor and Biomedical Technology

School of Electronics Engineering

Yadav J

Singh V

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Levenberg–Marquardt-Based Non-Invasive Blood Glucose Measurement System

IETE Journal of Research

Diabetes is a chronic metabolic disorder which can lead to severe complications and affect all vital organs. The occurrence of complications due to diabetes can be prevented by regular monitoring and maintaining the blood glucose level in the normal range. Most of the commercially available devices for glucose measurement are invasive or minimally invasive. Invasive devices used for blood glucose monitoring are inconvenient and painful whereas minimal invasive devices have limited time span and stability. Thus, there is a need of an economic, compact, painless and convenient non-invasive device which can promote frequent blood testing which help in control of blood glucose level. In this paper various methods of glucose monitoring are reviewed and overall emphasis is laid on the development of NIRS (near-infrared spectroscopy) based non-invasive glucose monitoring. The motivation of this review is to demonstrate the prospects, limitations and technical challenges for development of NIRS based non-invasive blood glucose measurement system. © 2015 Elsevier Ltd.

Biomedical Signal Processing and Control

Prospects and limitations of non-invasive blood glucose monitoring using near-infrared spectroscopy

Diabetes is a metabolic pathological condition of concern, which affects vital organs of body if not diagnosed and treated on time. Regular monitoring of blood glucose is important to avoid complication of diabetes. Commonly used glucose measurement methods are invasive which generally involves finger puncturing. These methods are painful and frequent pricking cause calluses on the skin and have risk of spreading infectious diseases. Therefore there is need to develop a non-invasive monitoring system which can measure blood glucose continuously without much problem. The present work is focused on development of non-invasive blood glucose measurement sensor system using Near-infrared (NIR) technique. Initially in-vitro glucose measurement prototype is developed using continuous wave (CW) from NIR LED (940 nm) to check the sensitivity of the system for different glucose concentrations. Later a Sensor patch was designed using LED and a photodiode to observe diffused reflectance spectra of blood from the human forearm. Diffused reflectance spectra of the subjects obtained with this technique was also compared with commercially available invasive finger tip gluco-meter. The results are promising and show the potential of using NIR for glucose measurement. © 2014 IEEE.

2014 International Conference on Signal Processing and Integrated Networks (SPIN)

Near-infrared LED based non-invasive blood glucose sensor

Diabetes Research and Clinical Practice

Update of mortality attributable to diabetes for the IDF Diabetes Atlas: Estimates for the year 2013

Smart Sensors, Measurement and Instrumentation Sensing Technology: Current Status and Future Trends IV

Noninvasive Estimation of Blood Glucose Concentration Using Near Infrared Optodes

ISA Transactions

Development of soft sensor for neural network based control of distillation column

Journal	IETE Journal of Research
Publisher	Informa UK Limited
ISSN	0377-2063
Open Access	0