Abstract: The main aim of massive multiuser multiple-input multiple-output (MU-MIMO) system is to improve the throughput and spectral efficiency in 5G wireless networks. The performance of MU-MIMO system is severely influenced by inter-antenna interference (IAI) and multiuser interference (MUI). The IAI occurs due to space limitations at each user terminal (UT) and the MUI is added when one UT is in the vicinity of another UT in the same cellular network. IAI can be mitigated through a precoding scheme such as singular value decomposition (SVD), and MUI is suppressed by an efficient multiuser detection (MUD) schemes. The maximum likelihood (ML) detector has optimal performance; however, it has a highly complex structure and involves the need of a large number of computations especially in massive structures. Thus, the neighborhood search-based algorithm such as likelihood ascent search (LAS) has been found to be a better alternative for mitigation of MUI as it results in near optimal performance with low complexity. Most of the recent papers are aimed at eliminating either MUI or IAI, whereas the proposed work presents joint SVD precoding and LAS MUD to mitigate both IAI and MUI. The proposed scheme can achieve a near-optimal performance with smaller number of matrix computations. © 2020, Pleiades Publishing, Ltd.