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Liposome mediated drug delivery for leukocyte adhesion deficieny I (LAD I): Targeting the mutated gene ITGB2 and expression of CD18 protein
, Kedarinath K, Choudhary P, Tyagi V,
Published in Springer Science and Business Media LLC
Volume: 9
Issue: 1
Pages: 1 - 4
Leukocyte adhesion deficiency (LAD) I is a disorder caused due to mutations in a gene (ITGB2) located on chromosome 21 and encodes the β2 subunit of the leukocyte integrin molecules. This leads to defects in the adhesion of leukocytes on endothelial cells which further leads to recurrent microbial infections due to a decrease in the immune response. Base Excision Repair Mechanism (BER) is instrumental in repairing damaged DNA by removing mutated/damaged bases. We have proposed a hypothesis for the treatment of LAD I by making use of the proteins/enzyme complexes responsible for base excision repair mechanism be introduced into the leukocytes via liposomes. This will target the mutated gene in the leukocytes (mostly neutrophils) and DNA repair will occur. The liposomes can be introduced into the patients via intravenous methods. © 2014 Higher Education Press and Springer-Verlag Berlin Heidelberg.
About the journal
JournalData powered by TypesetFrontiers in Biology
PublisherData powered by TypesetSpringer Science and Business Media LLC
Open AccessNo