This article investigates the theoretical study of the steady two-dimensional MHD convective boundary layer flow of a Casson fluid over an exponentially inclined permeable stretching surface in the presence of thermal radiation and chemical reaction. The stretching velocity, wall temperature and wall concentration are assumed to vary according to specific exponential form. Velocity slip, thermal slip, solutal slip, thermal radiation, chemical reaction and suction/blowing are taken into account. The proposed model considers both assisting and opposing buoyant flows. The non-linear partial differential equations of the governing flow are converted into a system of coupled non-linear ordinary differential equations by using the similarity transformations, which are then solved numerically by shooting method with fourth order Runge–Kutta scheme. The numerical solutions for pertinent parameters on the dimensionless velocity, temperature, concentration, skin friction coefficient, the heat transfer coefficient and the Sherwood number are illustrated in tabular form and are discussed graphically. © 2016 Faculty of Engineering, Ain Shams University