In recent years, much attention has been paid to the existence of peptides with biological activities and proteins derived from foods that might have beneficial effects for humans. Fishes are rich sources of structurally diverse bioactive compounds. The importance of fish as a source of novel bioactive substances is growing rapidly. Marine fish is a major source of high-quality peptides, proteins, lipids, and a wide variety of vitamins and minerals. Marine fish-derived bioactive peptides based on their structural properties and their amino acid composition and sequences, in addition to nutrient utilization, these peptides may be involved in various biological functions and including inhibition of angiotensin-I-converting enzyme (ACE) and and antioxidant and immunomodulatory, antimicrobial and and anticoagulant activities. Development of bioactive peptides from fish proteins and their health promoting ability is increasing. Protein and bioactive peptides from marine fish may promote the production of potentially lead to promising therapeutic applications. Marine fish usually find extensive use as therapeutic and diagnostic proteins. This review paper highlights the important functions and therapeutics potentials of Marine Fish-derived Bioactive Peptides and Proteins for human therapy.