In this paper, the dynamics of mathematical model for infection of thymus gland by HIV-1 is analyzed by applying some perturbation through two different types of delays such as in terms of Hopf bifurcation analysis. Further, the conditions for the existence of Hopf bifurcation are derived by evaluating the characteristic equation. The direction of Hopf bifurcation and stability of bifurcating periodic solutions are determined by employing the center manifold theorem and normal form method. Finally, some of the numerical simulations are carried out to validate the derived theoretical results and main conclusions are included. © 2014 World Scientific Publishing Company.