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Mathematical modeling of zika virus disease with nonlinear incidence and optimal control
Goswami N.K, Srivastav A.K, Shanmukha B.,
Published in IOP Publishing
2018
Volume: 1000
   
Issue: 1
Abstract
The Zika virus was first discovered in a rhesus monkey in the Zika Forest of Uganda in 1947, and it was isolated from humans in Nigeria in 1952. Zika virus disease is primarily a mosquito-borne disease, which is transmitted to human primarily through the bite of an infected Aedes species mosquito. However, there is documented evidence of sexual transmission of this disease too. In this paper, a nonlinear mathematical model for Zika virus by considering nonlinear incidence is formulated and analyzed. The equilibria and the basic reproduction number (R0) of the model are found. The stability of the different equilibria of the model is discussed in detail. When the basic reproduction number R0 < 1, the disease-free equilibrium is locally and globally stable i.e. in this case disease dies out. For R0 > 1, we have endemic equilibrium which is locally stable under some restriction on parameters. Further this model is extended to optimal control model and is analyzed by using Pontryagin's Maximum Principle. It has been observed that optimal control plays a significant role in reducing the number of zika infectives. Finally, numerical simulation is performed to illustrate the analytical findings. © Published under licence by IOP Publishing Ltd.
About the journal
JournalData powered by TypesetJournal of Physics: Conference Series
PublisherData powered by TypesetIOP Publishing
ISSN1742-6588
Open AccessYes