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Measurement of nucleation rate of ibuprofen in ionic liquid using induction time method
, T.K. Radhakrishnan, P. Kalaichelvi
Published in Elsevier B.V.
Volume: 521
Pages: 55 - 59
Nucleation is the initial step in the crystallization process of organics and inorganics from solution and is defined as the stochastic process of appearance of molecules of new solid phase from the saturated liquid phase. The measurement of nucleation kinetics is important to accurately model and control the product crystal properties. The primary nucleation kinetics can be measured by adopting a metastable zone width or induction time method. Induction time is defined as the time period between the creation of supersaturation and the onset of nucleation. It depends on various factors like concentration, temperature and solvent composition. The objective of the present study is to estimate the nucleation rate by the induction time method for non-steroidal anti-inflammatory drug ibuprofen grown in anionic liquid- BmimPF6 (1-butyl 3-methyl imidazolium hexafluoro phosphate). A set of experiments are performed at the1 ml scale for various supersaturations at two different temperatures and the induction times are measured. Since the nucleation in small stirred volume is highly stochastic in nature, the nucleation rates are determined from the probability distribution of measured induction times. Results show that heterogeneous nucleation mechanism is dominant. © 2019
About the journal
JournalData powered by TypesetJournal of Crystal Growth
PublisherData powered by TypesetElsevier B.V.