Rajendran P

Department of Mathematics

School of Advanced Sciences

Vellore Campus

Sen S.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Metallic Nanoparticles in the Food Industry

Nutraceuticals: Basic Research/Clinical Applications Nanotechnology in Nutraceuticals

Metal nanoparticles have a great impact and even change the composition of soil microbial communities. This poses the risk of their accumulation in the ecosystem, which may call on health hazard. Statistical techniques such as Plackett-Burman design, Response Surface Methodology were used for optimizing medium constituents for Bacillus cereus SVK1 and other critical variables responsible for the production of biomolecules and biosynthesis of hematite nanoparticles. The effect of hematite nanoparticles on the growth of soil bacteria were tested by agar-well diffusion method and dynamic growth curve techniques. Bacterial growth inhibition was not observed with hematite nanoparticle concentration of up to 25mg/mL. In addition, hematite nanoparticles enhanced the growth of the soil bacteria. The results show that hematite nanoparticles were non-toxic to soil bacteria indicating their scope for wide range of applications. The effective cytotoxic concentration (CTC50) of hematite nanoparticles against MCF-7, A549, Hep3B and Vero cell lines was found to be 207.58, 224.69, 193.26 and 2530μg/mL respectively. Hematite nanoparticles didn't cause lysis of red blood cells.

Colloids and Surfaces B: Biointerfaces

Evaluation of cytotoxicity of hematite nanoparticles in bacteria and human cell lines

Iron oxide nanoparticles were gaining significant importance in a variety of applications due to its paramagnetic properties and biocompatibility. Various chemical methods were employed for hematite nanoparticle synthesis which require special equipment or a complex production process. In this study, protein capped crystalline hexagonal hematite (α-Fe2O3) nanoparticles were synthesized by green approach using culture supernatant of a newly isolated bacterium, Bacillus cereus SVK1 at ambient conditions. The synthesized nanoparticles were characterized by electron microscopy, X-ray diffraction, UV-visible spectroscopy and Fourier transform infrared spectroscopic analysis. Nanoparticles were evaluated for its possible anticancer activity against HepG2 liver cancer cells by MTT assay. Hematite nanoparticles with an average diameter of 30.2 nm, exhibited a significant cytotoxicity toward HepG2 cells in a concentration-dependent manner (CTC50=704 ng/ml).

International Journal of Biological Macromolecules

Biosynthesis of hematite nanoparticles and its cytotoxic effect on HepG2 cancer cells

Development of reliable and eco-friendly process for the synthesis of metallic nanoparticles is an important step in the field of application of nanotechnology. We have developed modern method by using agriculture waste to synthesize silver nanoparticles by employing an aqueous peel extract of Annona squamosa in AgNO3. Controlled growth of silver nanoparticles was formed in 4 h at room temperature (25 °C) and 60 °C. AgNPs were irregular spherical in shape and the average particle size was about 35 ± 5 nm and it is consistent with particle size obtained by XRD Scherer equation. © 2012 Elsevier B.V. All rights reserved.

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Agricultural waste Annona squamosa peel extract: Biosynthesis of silver nanoparticles

Biointerface Research in Applied Chemistry

Characterization of Silver Nanoparticles Synthesized using Chemical Method and its Antibacterial Property

Compendium of Food Additive Specifications. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 87th Meeting June 2019. FAO JECFA Monographs 23

Outside Front Cover

Journal	Nutraceuticals: Basic Research/Clinical Applications Nanotechnology in Nutraceuticals
Publisher	CRC Press
Open Access	0