Objective: The objective of the current study is to deal with magnetohydrodynamic (MHD) nanoliquid flow over moving vertical plate with variable Prandtl numbers and viscosities. This analysis also includes the influence of thermal radiation. Quite significant variation in viscosity and Prandtl number in high-range temperature is observed. Thus, Prandtl number and viscosity are surmised to vary as an inversely proportional linear function of temperature. Problem definition: The MHD nanoliquid flow is considered along with the semi-infinite plate with the velocity Uw toward the x-direction, which is also the direction for free-stream velocity (Formula presented.). The geometrical sketch of the physical problem with the coordinate system is shown in Figure 1. The coordinate system has two coordinate axes: the (Formula presented.) -coordinate (x) and (Formula presented.) -coordinate (y). They are perpendicular to each other. The mathematical modeling of physical problem has been formulated by incorporating viscous terms into the governing equation related to thermal radiation, buoyant force, Brownian motion, thermophoresis, and magnetic parameter. Methodology: The mathematical modeling of current physical problem consists of highly nonlinear partial differential equations which have been solved numerically using quasilinearization technique along with finite difference method. The present outcome during numerical simulation is outlined in terms of velocity, temperature, and concentration profiles and they are analyzed with suitable physical reasons. Main results: The impact of various parameters on the velocity, temperature, and concentration profiles has been discussed with physical explanation. Velocity profile (Formula presented.) of the fluid enhances and concentration (Formula presented.) reduces with escalating buoyancy parameter (Formula presented.). In particular, 13% increment in velocity profile is observed as (Formula presented.) increases by 0.9 scale [(Formula presented.)], whereas 17% reduction in concentration profiles is noticed as (Formula presented.) increases by 0.5 scale [(Formula presented.)] at other fixed parameters. It is observed that magnetic parameter (Formula presented.) increases the temperature (Formula presented.) and concentration profiles (Formula presented.), whereas it works as deduction parameter for velocity profile (Formula presented.). The increasing value of thermophoresis (Formula presented.) and Lewis number (Formula presented.) works as catalyst for velocity, temperature, and concentration profiles. As thermophoresis (Formula presented.) increases from 0.5 to 2.0, temperature profile approximately increases 65% at other fixed parameters. As Lewis number (Formula presented.) increases from 0.5 to 4.0, then the temperature increases approximately 75% at other fixed parameters. © 2020 Wiley Periodicals LLC