Herein, an efficient, one-pot microwave-assisted synthesis of a diverse set of 3-bromoimidazo[1,2-a]pyridines is being reported with good yields (40-85%). The method involves electrophilic aromatic bromination using bromodimethylsulfonium ion generated in situ via oxidation of HBr salt by DMSO. This methodology was also applied to the synthesis of related imidazoheterocycles. Copyright © 2014 HeteroCorporation © 2014 HeteroCorporation.

Mohana Roopan S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Patil S.M

Mascarenhas M

Sharma R

Roychowdhury A.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Journal of Heterocyclic Chemistry

A new and highly efficient microwave promoted N-alkylation of triazolo-quinazolinones was developed by treating various phenyl-substituted heterocyclic amines with benzyl chloride using K2CO3 as a base in the presence of DMF. Also the heterocyclic amines were synthesized by condensing the 3-amino-1,2,4-triazole substituted benzaldehydes and 1,3-cyclohexanedione in the presence of microwave irradiation under solvent free condition. The synthesized heterocycles 4a–o and 6a–o were further confirmed by using different spectroscopic techniques such as NMR and HRMS. The compounds 6a–o was studied for their solvatochromic property with increasing polarity of solvents. The determinations of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging effect of the scaffolds 6a–o were carried out by UV–Vis spectrometer. In terms of IC50 all the compounds have shown remarkable antioxidant property compared with Ascorbic acid. © 2016 Elsevier B.V.

Journal of Molecular Liquids

Conventional spectroscopic identification of N-alkylated triazolo-quinazolinones and its antioxidant, solvatochromism studies

Aspergillosis is one of the infectious fungal diseases affecting mainly the immunocompromised patients. The scarcity of the antifungal targets has identified the importance of N-myristoyl transferase (NMT) in the regulation of fungal pathway. The dihydroquinazolinone molecules were designed on the basis of fragments responsible for binding with the target enzyme. The aryl halide, 1(a-g), aryl boronic acid and potassium carbonate were heated together in water and dioxane mixture to yield new C-C bond formation in dihydroquinazolinone. The bis(triphenylphosphine)palladium(II) dichloride was used as catalyst for the C-C bond formation. The synthesized series were screened for their in vitro antifungal activity against Aspergillus Niger and Aspergillus fumigatus. The binding interactions of the active compound with lysozyme were explored using multiple spectroscopic studies. Molecular docking study of dihydroquinazolinones with the enzyme revealed the information regarding various binding forces involved in the interaction.

Journal of Photochemistry and Photobiology B: Biology

Binding mode of dihydroquinazolinones with lysozyme and its antifungal activity against Aspergillus species

Organic Process Research & Development

Discovery and Development of an Efficient, Scalable, and Robust Route to the Novel CENP-E Inhibitor GSK923295A

Bioorganic & Medicinal Chemistry Letters

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Chemistry Letters

One-pot Synthesis of 3-Bromoimidazo[1,2-a]pyridine Derivatives Accompanied by Dimethyl Sulfoxide Oxidation

Clinica Chimica Acta

Author Index Volume 361 (2005)

Journal of Medicinal Chemistry

DNA Binding Ligands Targeting Drug-Resistant Bacteria: Structure, Activity, and Pharmacology

Microwave-Assisted One-Pot Synthesis of Substituted 3-Bromoimidazo[1,2-a]pyridines and Imidazoheterocycles

Journal	Data powered by TypesetJournal of Heterocyclic Chemistry
Publisher	Data powered by TypesetWiley
ISSN	0022-152X
Open Access	No