This article presents the nonlinear, steady state mixed convection boundary layer flow, heat and mass transfer of an incompressible non-Newtonian Jeffrey's fluid past a non-isothermal wedge. The transformed conservation equations are solved numerically subject to physically appropriate boundary conditions using a versatile, implicit finite-difference Keller box technique. The influence of a number of emerging non-dimensional parameters, namely Deborah number (De), ratio of relaxation to retardation times (λ), pressure gradient parameter (m), Buoyancy ratio parameter (N), mixed convection parameter (λ1), radiation parameter (F) and heat generation/absorption parameter (Δ) on velocity, temperature and concentration evolution in the boundary layer regime is examined in detail. Also, the effects of these parameters on surface heat transfer rate, mass transfer rate and local skin friction are investigated. © 2015 Faculty of Engineering, Ain Shams University